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AMPK activation during energy deficiency can both inhibit ferroptosis, through phosphorylation of ACACA/ACC (acetyl-CoA carboxylase alpha) in MEFs (mouse embryonic fibroblasts) and human renal adenocarcinoma cells [68], and promote ferroptosis, by targeting BECN1 (beclin1)-mediated system xc - inhibition in human colorectal cancer cells [25] or regulating pyrimidinosome assembly in human cervical cancer cells [69]

Magnoliae officinalis cortex (Houpo)s benefit was for lung disease, and intestinal function [20]

Fernhoff, N

This approach selectively targets pigmentation without causing thermal damage to surround tissues, minimizing the risk of inflammation and post-inflammatory hyperpigmentation

Acknowledgement Figure 1A is a courtesy of S

doi:10.4088/JCP.19m13207 2